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目的观察磷酸奥司他韦联合炎琥宁治疗儿童甲型流行性感冒(甲型流感)的临床效果。方法选取医院确诊为甲型流感的患儿200例,按随机数字表法分为观察组和对照组,每组100例。对照组给予炎琥宁注射液静脉滴注治疗,观察组在对照组治疗基础上给予磷酸奥司他韦颗粒口服治疗。观察2组治疗后临床效果、主要症状和体征持续时间、抗生素使用情况,并记录不良反应发生情况。结果治疗后,观察组总有效率为84.00%,高于对照组的70.00%(P<0.05);观察组鼻塞/流涕、发热持续时间均明显短于对照组(P<0.01);观察组抗生素使用率为14.00%,低于对照组的38.00%(P<0.01)。观察组不良反应发生率为12.00%,对照组不良反应发生率为14.00%,2组比较差异无统计学意义(P>0.05)。结论磷酸奥司他韦联合炎琥宁治疗儿童甲型流感效果明显,且安全性高。
Objective To observe the clinical effect of oseltamivir phosphate and mesylate on children with influenza A (influenza A). Methods 200 cases of children diagnosed as Influenza A in hospital were selected and randomly divided into observation group and control group according to random number table method, with 100 cases in each group. The control group was given Yanhuning injection intravenously, and the observation group was treated with oseltamivir phosphate orally on the basis of the control group. The clinical effects, the main symptoms and signs of the two groups were observed after treatment, the use of antibiotics, and record the occurrence of adverse reactions. Results After treatment, the total effective rate in the observation group was 84.00%, which was significantly higher than that in the control group (70.00%, P <0.05). The nasal obstruction, runny nose and fever duration in the observation group were significantly shorter than those in the control group (P <0.01) The antibiotic use rate was 14.00%, which was lower than 38.00% in the control group (P <0.01). The incidence of adverse reactions in the observation group was 12.00%, and the incidence of adverse reactions in the control group was 14.00%. There was no significant difference between the two groups (P> 0.05). Conclusions Oseltamivir phosphate combined with Yan Hu Ning is effective in treating children with influenza A and has high safety.