1 雌激素与骨质丢失无论是因切除卵巢,或因下丘脑—垂体的疾病,或给予促性腺激素释放激素(GnRH)显效剂,或自然绝经,由于雌激素水平的下降,均可引起骨质加速丢失。骨质加速丢失发生在全身的骨骼上,但松质骨丢失3～4倍于皮质骨。松质骨主要在椎体及长骨的末端。每年丢失可增加到5%～8%的骨总量,而皮质骨为1%～3%骨总量。经过10～15年,每年骨矿质的丢失逐渐减慢,达到0.3%的骨总量,然而持续此速度到 1 estrogen and bone loss Whether due to ovariectomy or hypothalamic-pituitary disease, or given gonadotropin-releasing hormone (GnRH) effective agent, or natural menopause, due to the decline of estrogen levels, can cause bone Mass acceleration lost. Bone acceleration loss occurs in the body’s bones, but cancellous bone loss of 3 to 4 times the cortical bone. Cancellous bone is mainly in the vertebral body and long bone ends. Lost each year can increase to 5% to 8% of the total bone, while cortical bone is 1% to 3% of the total bone. After 10 to 15 years, the annual bone mineral loss gradually slowed down to reach 0.3% of the total bone volume, but continued to this rate