Ft-207是抗癌药5-Fu的衍生物,在体内缓慢释放5-Fu而达到治疗目的,毒性较5-Fu小。Ft-207的血浓度曾用生物法、薄层扫描法、高压液相法测定。本文在前文报道用氟离子电极及S-2型pH计(±2mV)测定5-Fu血浓度的基础上,改用氟离子电极和S-3型pH计(±1mV)测定Ft-207中的氟,从而确定Ft-207的血浓度。测定灵敏度为0.038微克氟离子/毫升(此点在标准曲线上),此浓度与Ft-207 0.4微克/放 Ft-207 is a derivative of anticancer drug 5-Fu, slow release of 5-Fu in vivo for therapeutic purposes, toxicity than 5-Fu small. The blood concentration of Ft-207 was measured by the biological method, TLC and HPLC. In this paper, previously reported fluoride ion electrode and S-2 type pH meter (± 2mV) determination of 5-Fu blood concentration, using fluoride ion electrode and the S-3 pH meter (± 1mV) determination of Ft-207 Of fluorine to determine the blood concentration of Ft-207. The assay sensitivity was 0.038 μg Fluoride / mL (this is on the standard curve) and this concentration was similar to that of Ft-207 at 0.4 μg /