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目的评价液基薄层细胞检测系统(TCT)及TBS细胞学分类法在宫颈病变诊断中的应用价值。方法采用TCT检查宫颈细胞并进行TBS细胞学分类诊断,对阳性病例在阴道镜下取活检,以病检结果为金标准,对结果进行分析。结果TCT检查4 032例,发现有异常257例,占6.37%;其中ASCUS含AGUS 157例(3.89%),LSIL 54例(1.34%),HSIL 38例(0.94%),CA 8例(0.20%);在新疆医科大学第一附属医院接受阴道镜及活检的190例TCT异常者中C IN占45.3%,在104例ASCUS中检出C IN 38例(36.5%),47例LSIL中检出C IN 25例(53.2%);32例HSIL中检出C IN23例(71.9%);SCC 7例,最后活检7例全为癌;TCT法与活检有一定的相关性(P<0.01)。结论TCT检查能够帮助宫颈癌前病变的正确诊断,TCT检查异常的病例配合阴道镜病理检查进行最后诊断,能及早发现宫颈上皮内早期病变,是防治宫颈癌发生的关键。
Objective To evaluate the value of TCT and TBS cytology in the diagnosis of cervical lesions. Methods Cervical cells were detected by TCT and diagnosed by TBS cytology. Biopsies were taken under colposcopy in positive cases. The result of disease test was the gold standard. Results There were 257 cases (6.37%) with ASCUS being diagnosed in 4 032 cases, among which ASCUS contained 157 cases (3.89%) of AGUS, 54 cases (1.34%) of LSIL, 38 cases (0.94%) of HSIL and 8 cases ). CIN accounted for 45.3% of the 190 cases of TCT abnormalities undergoing colposcopy and biopsy in the First Affiliated Hospital of Xinjiang Medical University. CIN 38 cases (36.5%) were detected in 104 cases of ASCUS and 47 cases of LSIL C IN was detected in 25 cases (53.2%). Twenty-three cases of CIN were detected in 23 cases (71.9%) in 32 cases of HSIL. Seven cases of SCC were detected in all cases. All of the 7 cases were all carcinomatous by biopsy. There was a certain correlation between TCT and biopsy (P <0.01). Conclusion TCT can help diagnose cervical precancerous lesions correctly. TCT abnormalities can be diagnosed with colposcopy and early detection of early cervical intraepithelial lesions. It is the key to prevention and treatment of cervical cancer.