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结扎大鼠一侧大脑中动脉(MCAO)造成局灶性脑缺血模型,观察醒脑开窍针法对MCAO大鼠体重、神经病学症状、被动性条件反射、血液流变性、脑梗塞面积及脑组织病理学指标的影响。结果表明:醒脑开窍针法能明显改善MCAO大鼠神经病学症状,显著延长被动性条件反射潜伏期,减少错误次数,缩小脑梗塞面积,促进软化坏死灶内新生毛细血管和胶质细胞增生修复,减少坏死灶周围区脑组织水肿和炎症反应,而对血液粘度无明显影响。提示醒脑开窍针法对大鼠局灶性脑缺血具有明显的治疗作用
A rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) was established. The effects of Xingnao Kai Kai Acupuncture on body weight, neurological symptoms, reflex condition, hemorrheology, infarction area and brain of MCAO rats The impact of histopathological parameters. The results showed that: Xingnao Kai Kai Acupuncture can significantly improve the neurological symptoms of MCAO rats, significantly prolong the passive reflex latency, reduce the number of errors, reduce the infarct size, promote neovascularization and glial cell proliferation and repair, Reduce the brain tissue edema and inflammatory reaction in the area around the necrotic foci without any significant effect on the blood viscosity. Tip Xingnao Kaiqiao Acupuncture on focal cerebral ischemia in rats has a significant therapeutic effect