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目的:通过风药对肝纤维化的抑制,揭示风药活血化瘀的作用。方法:用50%CCl4橄榄油溶液皮下注射8周制造大鼠肝纤维化模型,造模成功后,将大鼠随机分为A(防风、羌活、白芷)组、B(下瘀血汤)组、C(秋水仙碱)组、D(生理盐水)组,E组(正常组)。观察各组药物治疗后变化情况和各组肝组织的病理学变化。结果:与模型组比较,下瘀血汤组和风药组大鼠血清HPC-Ⅲ、HA、ColⅣ-C、FN含量较模型组明显降低,光镜下可见风药组和下瘀血汤组灶性正常肝细胞索,未见肝假小叶形成。结论:风药对大鼠肝纤维化有较好的抑制作用,为中医药抗肝纤维化提供新的用药思路。
Objective: Through the inhibition of wind-induced liver fibrosis, revealing the role of traditional Chinese medicine for promoting blood circulation and removing blood stasis. Methods: Rat model of hepatic fibrosis was induced by subcutaneous injection of 50% CCl4 olive oil solution for 8 weeks. After successful modeling, the rats were randomly divided into A (windproof, Notopterygium, Angelica dahurica) group, B , C (colchicine) group, D (normal saline) group, E group (normal group). The change of each group after treatment and the pathological changes of each group were observed. Results: Compared with model group, the contents of serum HPC-Ⅲ, HA, Col Ⅳ-C and FN in Xiayuxue decoction group and Fuyao decoction group were significantly lower than those in model group. Normal liver cell cord, no hepatic pseudolobule formation. Conclusion: Feng Yao has better inhibitory effects on hepatic fibrosis in rats, and provides a new way for anti-hepatic fibrosis of traditional Chinese medicine.