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目的探讨高压氧对缺血缺氧性脑病新生儿智力及发育的影响。方法选择2013年6月—2015年12月本院收治的新生儿缺血缺氧性脑病76例作为调查对象,随机分为对照组和观察组各38例,对照组患儿给予常规治疗和早期干预,观察组在对照组基础上给予高压氧治疗。比较两组患儿的体格、智力、运动发育情况。计量资料两组间比较采用两独立样本t检验,组内比较采用配对t检验,P<0.05为差异有统计学意义。结果两组患儿动作能、应物能、应人能、言语能评分[(82.67±12.36)、(88.26±15.27)、(91.26±14.19)、(89.36±12.33)分与(109.48±24.98)、(103.52±32.98)、(105.15±24.67)、(99.86±22.18)分]比较,差异均有统计学意义(均P<0.05)。两组患儿卧位和翻身,坐位,爬和跪,站立,走、跳和跑评分[(89.51±10.27)、(87.64±14.18)、(85.63±14.13)、(64.26±9.65)、(31.96±8.34)分,(95.43±11.42)、(94.56±15.46)、(92.38±14.37)、(72.96±10.34)、(38.46±7.65)分]比较,差异均有统计学意义(均P<0.05)。结论早期应用高压氧治疗缺氧缺血性脑病可有效改善患儿的智力和运动发育情况,显著提高患儿的生活质量,减轻患儿家庭和社会的负担。
Objective To investigate the effects of hyperbaric oxygen on intelligence and development of neonates with hypoxic-ischemic encephalopathy. Methods Sixty-six neonates with hypoxic-ischemic encephalopathy admitted to our hospital from June 2013 to December 2015 were randomly divided into control group and observation group, with 38 cases in each group. The control group received routine treatment and early stage Intervention, observation group on the basis of the control group was given hyperbaric oxygen therapy. The physical, mental and physical development of the two groups were compared. Measurement data between the two groups were compared using two independent samples t test, the group was compared using paired t test, P <0.05 for the difference was statistically significant. Results There was no significant difference between the two groups in motor function, physical fitness, speech ability and speech ability [(82.67 ± 12.36), (88.26 ± 15.27), (91.26 ± 14.19), (89.36 ± 12.33) and (109.48 ± 24.98) , (103.52 ± 32.98), (105.15 ± 24.67) and (99.86 ± 22.18) points respectively. There were significant differences between the two groups (all P <0.05). The scores of standing, walking, jumping and running in two groups were significantly lower than those in the control group [(89.51 ± 10.27), (87.64 ± 14.18), (85.63 ± 14.13), (64.26 ± 9.65), (31.96 (P <0.05). There was significant difference between the two groups (P <0.05). There was significant difference between the two groups (P 0. 05), (95.43 ± 11.42), (94.56 ± 15.46), (92.38 ± 14.37), (72.96 ± 10.34) and (38.46 ± 7.65) . Conclusion The early application of hyperbaric oxygen therapy for hypoxic-ischemic encephalopathy can effectively improve children’s mental and motor development, significantly improve the quality of life of children, reduce the burden on families and society.