M bius综合征为少见的先天性疾病,家族性则更为罕见。作者将所见2例报告如下。病例摘要例1:男,46岁,住院号70112。42年前家人发现其双眼闭合不严,鼓腮不能,未经医治。查体:意识清楚,语言流利。双侧额纹消失,双眼闭合不全。双Bell氏征阳性。鼻唇沟变浅,鼓腮双侧均不能。运动、感觉和小脑系统无异常所见。腱反射正常,无病理反射引出。辅助检查:脑电图结果正常。头颅X光片未见异常。染色体46对正常核型。 M bius syndrome is a rare congenital disease, familial is even more rare. The author will see 2 cases reported as follows. Case Summary Example 1: Male, 46 years old, hospital number 70112. 42 years ago, the family found that their eyes closed lax, drums can not, without treatment. Examination: Consciousness, fluent language. Loss of bilateral forehead, eyes closed incomplete. Double Bell’s sign positive. Shallow nasolabial fold, drum gills both sides can not. Exercise, sensory and cerebellar system no abnormal seen. Tendon reflex normal, no pathological reflex leads. Auxiliary examination: EEG results are normal. No abnormal skull X-ray film. Chromosome 46 pairs of normal karyotypes.