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目的了解新生儿脐带血与孕母妊娠末期血维生素D水平的相关性,探讨影响新生儿脐血维生素D水平的相关因素。方法对自2015年11月-2016年3月冬季收住的112例新生儿脐血及其中40例的孕母产前静脉血采用化学发光法测定维生素D值,进行相关性分析。结果 112例新生儿脐血25(OH)D平均水平为(6.75±3.59)ng/ml,新生儿维生素D均处于缺乏状态,中、重度维生素D缺乏新生儿占85.7%。40例孕母血25(OH)D平均水平与新生儿血25(OH)D水平呈显著正相关(r=0.86,P<0.001);孕妇的民族、孕期补钙时间、海产品摄入次数与孕妇文化程度等对新生儿维生素D水平的影响有统计学意义;孕妇不同孕周、工作类型、户外活动时间、孕期是否抽筋及新生儿胎产次、胎儿性别、出生方式等对新生儿维生素D水平的影响无统计学意义(P>0.05)。结论冬季出生的新生儿维生素D缺乏严重,与孕妇妊娠末期静脉血维生素D水平显著相关。冬季应给予孕晚期孕妇补充足量维生素D,以提高新生儿维生素D水平。
Objective To investigate the correlation between neonatal umbilical cord blood and end-stage serum levels of vitamin D in pregnant women and explore the factors that affect the level of vitamin D in neonatal umbilical blood. Methods 112 cases of neonatal umbilical cord blood and 40 cases of prenatal venous blood collected from November 2015 to March 2016 in winter were measured by chemiluminescence method for the determination of vitamin D value. Results The average level of 25 (OH) D in 112 newborns was (6.75 ± 3.59) ng / ml, neonatal vitamin D were in a state of deficiency, and 85.7% of newborns with moderate and severe vitamin D deficiency. The average level of 25 (OH) D in 40 cases of maternal blood was positively correlated with the level of 25 (OH) D in neonates (r = 0.86, P <0.001). The nationality of pregnant women, the time of calcium supplement during pregnancy, And pregnant women with different educational level on the neonatal vitamin D levels were statistically significant; pregnant women different gestational age, type of work, outdoor activity time, pregnancy cramps and neonatal births, fetal sex, birth pattern on the neonatal vitamins D level had no significant effect (P> 0.05). Conclusion The neonatal newborn born in winter is deficient in vitamin D, which is significantly correlated with the level of vitamin D in pregnant women during the last trimester of pregnancy. Winter pregnant women should be given enough third trimester vitamin D supplementation to improve neonatal vitamin D levels.