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我们利用逆转录病毒介导的基因转染方法将含有自杀基因ＨＳＶＴＫ与潮霉素抗性基因Ｈｙ的融合基因ＨｙＴＫ导入正常人Ｔ淋巴细胞，以期利用自杀基因的作用底物来减少受者体内供者Ｔ细胞的数量，从而达到防治移植物抗宿主病（ＧＶＨＤ）而保留移植物抗白血病（ＧＶＬ）的目的?
We use a retrovirus-mediated gene transfer method to contain suicide gene HSV TK and hygromycin resistance gene Hy fusion gene HyTK into normal human T lymphocytes, in order to use the suicide gene as a substrate to reduce the role of the recipient The number of donor T cells in vivo, so as to achieve the purpose of prevention and treatment of graft versus host disease (GVHD) and retain the graft anti-leukemia (GVL)?