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用流式细胞仪分析31例系统性红斑狼疮(SLE)患者外周血淋巴细胞的OKT_3、OKT_4和OKT_3表型,同时以36名健康成人做对照。结果表明,患者OKT_3~+、OKT_~4+细胞阳性百分率在正常范围内.但患者OKT_8~+细胞百分率显著高于正常值(分别为44.52士12.07、30.39±6.06,P<0.01),OKT_4+/OKT_8~+比值显著低于正常值(分别为0.69±0.24、1.06±0.28,P<0.01)。13例有肾脏损害患者中5例OKT_4~+/OKT_8~+比值明显降低,占38.5％;而无肾脏损害18例中仅1例OKT_4~+/OKT_8~+比值明显降低,占5.56％.
OKT_3, OKT_4 and OKT_3 phenotypes of peripheral blood lymphocytes in 31 patients with systemic lupus erythematosus (SLE) were analyzed by flow cytometry. At the same time, 36 healthy adults were used as controls. The results showed that the positive percentage of OKT_3 ~ + and OKT_4 + cells was within the normal range, but the percentage of OKT_8 ~ + cells in patients was significantly higher than the normal values (44.52 ± 12.07 and 30.39 ± 6.06, P <0.01) OKT_8 ~ + ratio was significantly lower than the normal value (0.69 ± 0.24,1.06 ± 0.28, P <0.01). The ratio of OKT_4 ~ + / OKT_8 ~ + was significantly decreased in 5 of 13 patients with renal damage, accounting for 38.5%. Only 1 of 18 patients without renal damage showed a marked decrease in the ratio of OKT_4 ~ + / OKT_8 ~ + accounting for 5.56%.