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乙型肝炎病毒(HBV)的衣壳蛋白包括S蛋白与前S蛋白,后者又分为前S1蛋白和前S2蛋白。前S1抗原(PreS1)含有肝细胞膜受体,只存在于具有传染性的完整的乙肝病毒颗粒上,在病毒感染、装配、复制和刺激集体产生免疫应答方面具有十分重要作用[1,2]。我国是病毒性肝炎的高发区,特别是乙型病毒性肝炎,不仅其人群感染率高,而且易转为慢性肝炎,部分患者可演变为肝硬化甚至是原发性肝[3,4]
The capsid proteins of Hepatitis B virus (HBV) include the S protein and the pre-S protein, which is further divided into pre-S1 protein and pre-S2 protein. PreS1 antigen (PreS1), which contains hepatocyte membrane receptors and exists only on infectious intact hepatitis B virus particles, plays a very important role in viral infection, assembly, replication and stimulation of the collective production of immune responses [1,2]. China is a high incidence of viral hepatitis, especially hepatitis B, not only its high rate of population infection, but also easily converted to chronic hepatitis, some patients can evolve into cirrhosis or even primary liver [3,4]