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本文指出药物的相互作用可发生于药物的吸收部位。给大鼠腹腔注射苯海拉明2～25毫克/公斤体重,接着口服对氨基水杨酸(PAS)200毫克/公斤,以后隔不同时间处死动物,收集血样及部分动物的肝、肌肉、脂肪、肺、脑及肾等组织,测定PAS的浓度,另外用透析法测定PAS的血浆蛋白结合率,并在服用PAS后45分钟,检查胃肠道内PAS的存留量。结果表明,苯海拉明能降低PAS的血浓度,其作用大小与剂量成正比。注射苯海拉明25毫克/公斤体重后1小时内,PAS的血浓度显著低于对照组,但PAS的血浆蛋白结合率略高于对照组,除脂肪外,PAS在上述
This paper indicates that drug interactions can occur at the site of drug absorption. The rats were injected intraperitoneally with diphenhydramine 2 ~ 25 mg / kg body weight, followed by oral administration of aminosalicylic acid (PAS) 200 mg / kg, and animals were sacrificed at different time intervals to collect blood samples and some animals’ liver, muscle and fat , Lung, brain and kidney tissues were collected and the concentration of PAS was measured. In addition, the plasma protein binding rate of PAS was measured by dialysis, and the retention of PAS in the gastrointestinal tract was examined 45 minutes after taking PAS. The results show that diphenhydramine can reduce the blood concentration of PAS, its role is proportional to the size and dose. Within one hour after injection of diphenhydramine 25 mg / kg body weight, PAS blood concentration was significantly lower than the control group, but the PAS plasma protein binding rate slightly higher than the control group, in addition to fat, PAS in the above