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慢性苯中毒的发病机制,迄今仍未完全阐明、故缺乏早期特异性的诊断指标。国内外已有不少关于苯中毒时机体免疫功能有所降低的报导,近十余年来,由于免疫学的发展,如对结核杆菌纯化蛋白质衍生物(PPD)、白喉或破伤风类毒素、肿瘤细胞等都能作为淋巴细胞转化试验所用的特异性抗原,特别是以阿斯匹林、非那西汀等药物代替植物血凝素(PHA)在体外使已对该药致敏的淋巴细胞转化为淋巴母细胞获得成功,证实了药物半抗原作用。我们设想苯中毒病人白细胞减少也是由于苯或苯的代谢产物的致敏作用,从而也可用苯或苯的代谢物代替PHA,进行体外淋巴细胞转化试验。作为诊断中毒的方法之一。为
The pathogenesis of chronic benzene poisoning, has not yet fully elucidated, it is the lack of early diagnosis of specific indicators. At home and abroad, there have been a lot of reports about the decrease of body immunity in benzene poisoning. In the recent ten years, due to the development of immunology, such as the purification of PPD, diphtheria or tetanus toxoid, Tumor cells can be used as lymphocyte transformation test specific antigen, in particular aspirin, phenacetin and other drugs instead of phytohemagglutinin (PHA) in vitro so that the drug has been sensitized lymphocytes Successful conversion to lymphoblasts confirmed the effect of the drug hapten. We hypothesize that leukopenia in benzene-poisoned patients is also due to the sensitization of benzene or benzene metabolites, so that in vitro lymphocyte transformation assays may also be performed using benzene or benzene metabolites instead of PHA. As one of the methods to diagnose poisoning. for