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目的 :探讨幽门螺杆菌 ( Hp)细胞毒素相关基因 A阳性株 ( cag A+ 株 )与胃癌的关系。方法 :通过多聚酶链反应 ( PCR)检测 92例胃癌和 2 4例浅表胃炎组织石腊标本 Hp和 cag A+亚型株的感染。结果 :1Hp感染在胃癌和慢性浅表胃炎间无差异 ,而 cag A+株感染是前者高于后者 ( P<0 .0 5 ) ;2 Hp感染早期胃癌高于进展期癌、胃窦癌高于贲门癌、肠型胃癌高于弥漫型癌 ( P<0 .0 5 )。然而只有肠型胃癌 cag A+ 株感染显著高于弥漫型癌 ( P=0 .0 0 13 5 )。结论 :胃癌不同组织类型感染 Hp亚型的程度不同 ,Hp- cag A+ 株感染率在肠型胃癌中显著增高。从而推测产生细胞毒素的 Hp菌株 ,可能是胃癌尤其是肠型胃癌的发生发展过程中重要的危险因素
Objective: To investigate the relationship between Helicobacter pylori (Hp) cytotoxin-related gene A positive strain (cag A +) and gastric cancer. Methods: The infection of 92 cases of stomach cancer and 24 cases of superficial gastritis paraffin specimens Hp and cag A + subtype was detected by polymerase chain reaction (PCR). Results: The infection rate of 1Hp infection was no difference between gastric cancer and chronic superficial gastritis, while the infection rate of cag A + strain was higher than that of the latter (P <0.05). The early stage of Hp infection was higher than that of advanced stage and gastric antrum In cardiac cancer, intestinal type gastric cancer was higher than diffuse type cancer (P <0.05). However, infection of cag A + strains of enteric gastric cancer was significantly higher than that of diffuse carcinoma (P = 0.0135). CONCLUSIONS: The degree of Hp subtypes infection by different tissue types of gastric cancer is different, and the infection rate of Hp-cag A + strain is significantly higher in intestinal type gastric cancer. It is speculated that the cytotoxic Hp strain may be an important risk factor in the development of gastric cancer, especially intestinal type gastric cancer