抗生育药物的应用对象是正常健康人。为了确保用药者及其后代的安全,对这类药物应当进行严格的安全性试验,特别是潜在性远期危害试验(致突变、致畸、致癌试验)。Ames试验是当今普遍选用来测试化学物质是否有致突变性的方法,具有简易、快速、敏感而经济等优点。我们采用此方法对国产一些常用及新合成的抗生育药物进行了测试,旨在评价它们是否具有致突变作用。 Anti-fertility drugs are the target of normal healthy people. In order to ensure the safety of drug users and their offspring, stringent safety tests should be conducted on such drugs, especially potential long-term hazards tests (mutagenicity, teratogenicity, carcinogenicity test). Ames test is now commonly used to test whether there is mutagenic chemical methods, with simple, fast, sensitive and economical advantages. We used this method to test some commonly used and newly synthesized anti-fertility drugs made in China to evaluate whether they have mutagenic effects.