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ABSTRACT Objective:To investigate effect of orthodontic force on inflammatory periodontal tissue remodeling and expression ofIL-6 andIL-8 in rats.Methods:EightySD rats were randomly divided into4 groups, blank control group(groupA) with5 rats, treatment normal group(group B) with25 rats, inflammation control group(group(groupC) with25 rats, inflammation treatment group(groupD) with25 rats.Immunohistochemistry and histomorphometric analysis was performed to measure the expression ofIL-6,IL-8 and the first molar to the recent movement in the distance.Results:The expression ofIL-8 reached a maximum on day5 and declined thereafter in groupB; the expression ofIL-6 reached a maximum on day5 in groupB.The expression ofIL-6 andIL-8 was gradually weakened with time in groupC.The expression of IL-6 andIL-8 were high, and reached a maximum on day5 and declined thereafter in groupD. AD of positive cells in groupD were higher than groupB at each time point(P<0.05).The time which0.49N orthodontic force was loaded was longer, orthodontic tooth movement distance was greater.Movement distance in groupD were longer than groupB(P<0.05).Conclusions:Orthodontic force as well as inflammatory stimulus can evoke the expression ofIL-6 andIL-8. Under the combined effects of inflammation and orthodontic force, the expression ofIL-6,IL-8 will increase.