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为探讨降钙素基因相关肽（ＣＧＲＰ）与哮喘的关系，用放射免疫分析法，动态观察了３８例哮喘急性发作期及临床缓解期患儿血浆ＣＧＲＰ含量变化。结果：哮喘急性发作期血浆ＣＧＲＰ含量较其临床缓解期、轻型支气管肺炎组及健康组均显著降低（Ｐ＜０．０１）；重度哮喘急性发作期血浆ＣＧＲＰ含量显著低于轻度哮喘（Ｐ＜０．０１）；随哮喘的缓解，血浆ＣＧＲＰ含量随之上升并接近健康组水平；哮喘临床缓解期、轻型支气管肺炎及正常对照组间血浆ＣＧＲＰ含量无显著差异（Ｐ＞０．０５）。结论：血浆ＣＧＲＰ含量的降低可能对哮喘的发作有一定的促进作用，而增高则可能有利于哮喘的缓解。
To investigate the relationship between calcitonin gene-related peptide (CGRP) and asthma, the levels of plasma CGRP in 38 asthmatic children with acute exacerbation and clinical remission were dynamically observed by radioimmunoassay. Results: The levels of plasma CGRP in patients with acute asthma exacerbation were significantly lower than those in patients with mild asthma, mild bronchopneumonia and healthy controls (P <0.01). The levels of plasma CGRP in acute exacerbation of asthma were significantly lower than those in mild asthma (P < 0.01). With the alleviation of asthma, plasma CGRP level increased and approached the level of healthy group. There was no significant difference in plasma CGRP levels between the clinical remission, mild bronchopneumonia and normal control group (P> 0.05). Conclusion: The decrease of plasma CGRP level may promote the onset of asthma, and the increase may be beneficial to the relief of asthma.