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探讨儿童克罗恩病 (Crohn disease,CD)及溃疡性结肠炎 (ulcerative colitis,UC)血中抗氧化物的变化。方法 对 8例CD和 7例 UC患儿进行营养学评分 ,另选 8例正常儿童作为对照。测定其血中抗坏血酸 ,谷胱甘肽及谷胱甘肽过氧化物酶 ,视黄醇及视黄醇结合蛋白和血硒的含量 ,并与正常对照组进行比较。结果 CD患儿其营养状态明显差于 UC及正常儿童 ,同时血浆中抗坏血酸含量明显降低 ,而谷胱甘肽及谷胱甘肽过氧化物酶、α-生育酚含量明显增高 ,UC患儿尽管亦有增高趋势 ,但与正常对照组比较并无明显的差异。结论 CD患儿血中抗氧化物出现明显改变 ,对于判断疾病的性质具有重要的临床意义。
To investigate the changes of blood antioxidants in children with Crohn disease (CD) and ulcerative colitis (UC). Methods Eight patients with CD and seven patients with UC were scored for nutrition and another eight normal children were selected as controls. The blood levels of ascorbic acid, glutathione and glutathione peroxidase, retinol and retinol binding protein and blood selenium were measured and compared with the normal control group. Results The nutritional status of children with CD was significantly worse than that of UC and normal children, meanwhile, the content of ascorbic acid in plasma was significantly decreased, while the contents of glutathione, glutathione peroxidase and α-tocopherol were significantly higher in children with UC Also increased trend, but no significant difference compared with the normal control group. Conclusion There is a significant change of blood antioxidants in children with CD, which has important clinical significance for judging the nature of disease.