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目的分析纳美芬在治疗急性酒精中毒患者中的疗效及安全性。方法将2009年4月至2010年4月收治的120例急性酒精中毒患者随机分成对照组和治疗组,其身体状况、饮酒情况等差异均无统计学意义。两组在常规治疗的基础上,对照组兴奋期和共济失调期、昏迷期分别给予纳洛酮0.8 mg、1.2 mg加入0.9%氯化钠液250 ml静脉滴注,严重者需重复用药;治疗组兴奋期和共济失调期、昏迷期分别给予纳美芬0.1 mg、0.2 mg加入0.9%氯化钠液250 ml中静脉滴注。观察患者意识恢复、语言能力、共济失调及不良反应情况。结果在2 h和5 h内,两组的治愈率和总有效率相比,差异有统计学意义。结论纳美芬在治疗急性酒精中毒中疗效显著,作用时间长,不良反应少,安全可靠。
Objective To analyze the efficacy and safety of nalmefene in the treatment of patients with acute alcoholism. Methods A total of 120 acute alcohol poisoning patients who were treated from April 2009 to April 2010 were randomly divided into control group and treatment group. There was no significant difference in their physical status and drinking status. On the basis of routine treatment, the two groups were given naloxone 0.8 mg and 1.2 mg respectively with 250 ml 0.9% sodium chloride solution in the excitement phase and ataxia period and coma of the control group. In severe cases, repeated treatment was required. The excitement phase of the treatment group and ataxia period, coma were given nalmefene 0.1 mg, 0.2 mg added 0.9% sodium chloride solution 250 ml intravenous infusion. Observe the recovery of patients consciousness, language ability, ataxia and adverse reactions. Results Within 2 h and 5 h, the cure rates of the two groups were significantly different from the total effective rate. Conclusion Nalmefene has a significant effect in the treatment of acute alcoholism. It has a long duration of action, few side effects, and is safe and reliable.