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对73例慢性乙型肝炎患者随机分为两组,即异体LAK细胞联合IL-2治疗组48例和一般护肝药物对照组25例。在治疗前及治疗后一个月检测乙型肝炎病毒DNA,两对半血清HBV标志物、肝功能等项目。结果显示治疗组HBeAg阴转率为60.4%(P<0.01),HBcAg、抗HBc-IgM及HBVDNA的阴转率分别为37.5%、29.2%和41.7%(P<0.05)。HBsAg阴转率为6.3%与对照组无显著性差异(P>0.05)。治疗组肝功能恢复效果较对照组佳。
73 patients with chronic hepatitis B were randomly divided into two groups, namely, allogeneic LAK cells combined IL-2 treatment group 48 cases and general liver protection drug control group 25 cases. Hepatitis B virus DNA, two pairs of serum half-serum HBV markers and liver function were tested before treatment and one month after treatment. The results showed that the negative conversion rate of HBeAg in treatment group was 60.4% (P <0.01), and the negative conversion rates of HBcAg, anti-HBc-IgM and HBVDNA were 37.5%, 29.2% and 41.7% P <0.05). The rate of negative conversion of HBsAg was 6.3% and there was no significant difference between the two groups (P> 0.05). The treatment group liver function recovery better than the control group.