目的对比大剂量奥美拉唑和常规剂量奥美拉唑治疗急性非静脉曲张性上消化道大出血的治疗效果。方法采用分组对照的临床研究方法,所有病例均符合急性非静脉曲张性上消化道大出血诊断标准。大剂量组65例,首剂80 mg奥美拉唑静脉注射,然后以8 mg/h微泵持续静推;常规剂量组61例,每12小时静脉注射奥美拉唑40 mg。观察两组病例的止血所需时间、再出血情况及输血量。结果大剂量组显效51例,有效11例,总有效率为95.4%;常规剂量组显效30例,有效19例,总有效率为80.3%,两组间差异有统计学意义。大剂量组平均每例输红细胞悬液(2.3±1.5)U,常规剂量组平均每例输红细胞悬液(4.2±1.3)U;大剂量组48 h再出血率1.15%,常规剂量组48 h再出血率7.84%。两组患者均无明显不良反应。结论大剂量奥美拉唑对急性非静脉曲张性上消化道大出血止血效果明显,无明显副作用,且能缩短住院时间。 Objective To compare the therapeutic effect of high-dose omeprazole and conventional omeprazole in the treatment of acute non-variceal upper gastrointestinal hemorrhage. Methods A group controlled clinical study was conducted. All cases were in accordance with the diagnostic criteria of acute non-variceal upper gastrointestinal bleeding. In the high-dose group, 65 cases were treated with 80 mg omeprazole as the first dose and then intravenously by 8 mg / h micro-pump. In the conventional dose group, 61 cases received omeprazole 40 mg intravenously every 12 hours. The time required for hemostasis, rebleeding and blood transfusion were observed in two groups. Results In the high-dose group, 51 cases were markedly effective and 11 cases were effective. The total effective rate was 95.4%. In the conventional dosage group, 30 cases were markedly effective and 19 cases were effective. The total effective rate was 80.3%. There was significant difference between the two groups. In the high-dose group, the average transfusion rate of red blood cells was (2.3 ± 1.5) U, while the average transfusion rate of red blood cells in each group was (4.2 ± 1.3) U, that of the high-dose group was 1.15% Rebleeding rate of 7.84%. No significant adverse reactions in both groups. Conclusion High-dose omeprazole has obvious hemostatic effect on acute non-variceal upper gastrointestinal hemorrhage with no obvious side effects and shortened hospitalization time.