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目的:探讨孕妇IgG血型抗体效价与ABO新生儿溶血病发生率之间的关系。方法:对2741例妻O型Rh阳性夫非O型孕妇做IgG抗-A(B)效价测定,对其中286例有HDN危险的孕妇所生新生儿做HDN血型血清学检查(即ABO血型鉴定、Coomb’s试验、游离和释放试验),以了解孕妇IgG血型抗体效价高低与ABO-HDN发病率之间的关系。结果:2741例O型孕妇中,IgG抗-A(B)效价<64、64、128、256和≥512各组分别占61.9%、17.0%、12.6%、6.1%和2.4%。286例母婴血型不合且有ABO-HDN危险的孕妇所生新生儿中共有71例HDN阳性,占24.8%;孕妇IgG抗-A(B)效价为64、128、256和≥512各组HDN阳性率分别为10.7%、28.3%、44.9%和64.3%(P<0.01)。结论:孕妇血清中IgG抗-A(B)效价高低与ABO-HDN的发生率成正相关,产前进行血清IgG抗体效价检测非常必要。
Objective: To explore the relationship between IgG antibody titer in pregnant women and the incidence of hemolytic disease in neonates with ABO. Methods: Totally 2741 pregnant women with O-positive and non-O-positive pregnant women were tested for IgG anti-A (B) titer. HDN serology was performed on 286 newborn infants born to pregnant women with HDN risk (ie, ABO blood group Coomb’s test, release and release test) to understand the relationship between the pregnant women IgG blood group antibody titer and the incidence of ABO-HDN. RESULTS: Of 2741 O-pregnant women, the titer of IgG anti-A (B) was 61.9%, 17.0%, 12.6%, 6.1% and 2.4% in the groups of <64,64,128,256 and ≥512, respectively. Of the 286 newborn infants born to pregnant women who had abnormal blood type with ABO-HDN, 71 were HDN positive, accounting for 24.8%; IgG anti-A (B) titer of pregnant women was 64,128,256 and ≥512 HDN positive rates were 10.7%, 28.3%, 44.9% and 64.3% (P <0.01). Conclusion: The serum level of IgG anti-A (B) in pregnant women is positively correlated with the incidence of ABO-HDN. Prenatal serum IgG antibody titer is very necessary.