维生素E 缺乏(α—生育酚),是引起某些致残神经综合征的重要原因。1922年发现为鼠类正常生殖功能的一种重要因子,在各种动物实验证明,它的缺乏可引起无痛性肌萎缩,近端肌肉软弱综合征,其组织学表现,为肌肉和脊髓退行性改变(特别是脊髓后柱)。这些损害的严重性,与维生素E 缺乏持续时间和动物成熟期有明显关联。补足维生素E,年幼动物较成年动物恢复较快。在人类与维生素E 缺乏有关的神经综合征,最先发现于血内β—脂蛋白缺乏症患者。10多年来,Muller 等报告提出,维生素E 缺乏与血内β—脂蛋白缺乏症的脊髓小脑综合征和其他脂类吸收障碍之间有明显相关。在血β—脂蛋白缺乏症,总脱辅基蛋白—B(apoprotein—B)缺乏,导致脂类以及维生 Vitamin E deficiency (alpha-tocopherol) is an important cause of certain disabling neurological syndromes. An important factor found in 1922 for normal reproductive function in mice, experiments in a variety of animals have shown that its deficiency can cause painless muscle atrophy, proximal muscular weakness syndrome, its histological manifestations, degenerative muscle and spinal cord Sexual changes (especially posterior spinal column). The severity of these injuries is clearly related to the duration of vitamin E deficiency and maturation of animals. Make up vitamin E, young animals recover faster than adult animals. Neurological syndromes associated with vitamin E deficiency in humans were first identified in patients with β-lipoprotein deficiency in the blood. For more than a decade, Muller et al. Reported that there was a clear correlation between vitamin E deficiency and Splenomegaly and other lipid-malabsorption in the blood with beta-lipoprotein deficiency. In the blood β-lipoprotein deficiency, the lack of total apoprotein-B (apoprotein-B), leading to lipid and maintenance