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目的 探讨经肝动脉化疗栓塞后 TGF- β1 、TGF- α在肝癌细胞凋亡中的作用。方法 应用免疫组织化学方法检测 19例未经肝动脉化疗栓塞 (TACE)和 36例经 TACE治疗的肝癌组织中 TGF-β1 、TGF-α的表达 ,采用 ISEL法检测肝癌细胞凋亡。结果 经 TACE治疗和未经 TACE治疗的肝癌组织中 TGF- β1 表达率分别为 86 .11%和 36 .84% ;TGF- α表达率分别为 36 .11%和84.2 1% ;肝癌细胞凋亡指数分别为 0 .0 0 88和 0 .190 1。结论 经 TACE治疗后 TGF- β1 表达增强 ,促进了肝癌细胞凋亡。 TGF-α主要与肝癌细胞增殖有关 ,其表达减弱亦可能促进了肝癌细胞凋亡
Objective To investigate the role of TGF-β1 and TGF-α in hepatocellular carcinoma after transcatheter arterial chemoembolization. Methods The expression of TGF-β1 and TGF-α in 19 cases of hepatocellular carcinoma without TACE and 36 cases of TACE were detected by immunohistochemistry. The apoptosis of hepatocellular carcinoma was detected by ISEL. Results The positive rates of TGF-β1 in HCC tissues treated with or without TACE were 86.11% and 36.84%, respectively. The positive rates of TGF-α were 36.11% and 84.2% The indices were 0 .0 0 88 and 0.190 1 respectively. Conclusion After TGF-β1 treatment, the expression of TGF-β1 is enhanced, which promotes the apoptosis of hepatoma cells. TGF-α is mainly related to the proliferation of hepatocellular carcinoma cells, and the decreased expression of TGF-α may also promote the apoptosis of hepatoma cells