缺氧诱导因子(HIF-1)是细胞在缺氧环境中产生的具有转录活性的核蛋白。在多因素作用下肿瘤细胞中HIF-1α表达上调,而HIF-1调节的基因涉及血管的发生、能量代谢、红细胞生成、细胞增殖和发育、血管重塑、儿茶酚胺代谢等,从而促进肿瘤生长、浸润及转移。在大多数人类肿瘤中存在HIF-1α的过表达,在妇科肿瘤中也不例外。在肿瘤的治疗中,以HIF-1作为肿瘤治疗靶点的研究已在进行。 Hypoxia-inducible factor (HIF-1) is a transcriptionally active nuclear protein produced by cells in hypoxia. The expression of HIF-1α in tumor cells is up-regulated under the multifactorial action. The genes involved in the regulation of HIF-1 are involved in the development of blood vessels, energy metabolism, erythropoiesis, cell proliferation and development, vascular remodeling and catecholamine metabolism, Infiltration and transfer. Overexpression of HIF-1α exists in most human tumors and is no exception in gynecological tumors. In the treatment of cancer, the study of HIF-1 as a target of tumor treatment has been carried out.