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本文用RIA法测定30例健康人、CRF24例非透析病人和14例血透病人的血浆ANP、PRA、ATⅡ、ALD水平。结果表明CRF病人ANP、PRA、ATⅡ、ALD明显高于对照胆（P<0.05～0.01）,其中高血压组ANP明显高于非高血压组（P<0.05）,血透后ANP明显下降（P<0.01）。ANP和Scr、MAP呈正相关,ANP、ATⅡ均和A呈负相关。结合文献初步探讨了CRF时,ANP和PAS的临床意义。
In this paper, plasma ANP, PRA, AT Ⅱ, ALD levels were measured in 30 healthy subjects, 24 CRF non-dialysis patients and 14 hemodialysis patients by RIA. The results showed that ANP, PRA, ATⅡ and ALD were significantly higher in CRF than those in control group (P <0.05-0.01). The ANP in hypertension group was significantly higher than that in non-hypertension group (P <0.05) <0.01). ANP and Scr, MAP was positively correlated, ANP, AT Ⅱ and A were negatively correlated. Combined with the literature preliminarily explore the clinical significance of ANP and PAS when CRF.