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目的:探讨抗血管内皮生长因子(VEGF)药物联合复合式小梁切除术及全视网膜激光光凝术(PRP)治疗新生血管性青光眼的临床效果。方法:抽取2016年3月至2019年2月平顶山市第一人民医院收治的新生血管性青光眼患者56例(56只眼)。根据随机数字表法分为观察组29例(29只眼)和对照组27例(27只眼)。对照组为抗VEGF药物联合复合式小梁切除术治疗，观察组在对照组基础上联合PRP治疗。比较两组术前及术后1周、3个月眼压，术后3个月视力、虹膜新生血管、功能性滤过泡和并发症。结果:术后1周及术后3个月两组眼压均低于术前，且术后3个月观察组眼压较对照组低，差异有统计学意义(n P0.05)。术后3个月，观察组功能性滤过泡发生率(62.07%)明显高于对照组(26.63%)，差异有统计学意义(n P<0.05)。观察组总并发症发生率(24.14%)明显低于对照组(55.56%)，差异有统计学意义(n P<0.05)。n 结论:抗VEGF药物联合复合式小梁切除术及PRP治疗新生血管性青光眼疗效较好，可有效控制眼压，减少并发症发生。“,”Objective:To explore the clinical effect of anti-vascular endothelial growth factor (VEGF) drugs combined with compound trabeculectomy and pan retinal photocoagulation (PRP) in the treatment of neovascular glaucoma.Methods:Fifty-six patients (56 eyes) with neovascular glaucoma admitted to Pingdingshan First People’s Hospital from March 2016 to February 2019 were selected. According to the random number table method, they were divided into the observation group (n n=29, 29 eyes) and the control group (n n=27, 27 eyes). The control group was treated with anti-VEGF drugs combined with compound trabeculectomy, and the observation group was treated with PRP treatment on the basis of the control group. The intraocular pressure before and 1 week and 3 months after the operation, the visual acuity, iris neovascularization 3 months after operation, functional filtering blebs and complications were compared.n Results:One week and three months after operation, the intraocular pressures of the two groups were lower than those before operation, and the intraocular pressure of the observation group was lower than that of the control group 3 months after operation, the difference was not statistically significant (n P0.05). Three months after operation, the incidence of functional filtering blebs in the observation group was significantly higher than that in the control group (62.07%n vs 26.63%), the difference was not statistically significant ( n P<0.05). The total incidence of complications in the observation group was significantly lower than that in the control group (24.14%n vs 55.56%), the difference was not statistically significant ( n P<0.05).n Conclusions:The combination of anti-VEGF drugs with trabeculectomy and PRP is effective in treating neovascular glaucoma, which can effectively control intraocular pressure and reduce complications.