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目的:探讨太行山区食管癌高发区食管癌患者的恶性肿瘤遗传易感性对预后的影响。方法:回顾性调查太行山区林州市及其周边食管癌高发区的742例食管癌患者的年龄、性别、食管癌家族史、恶性肿瘤家族史、生存时间等内容,运用t检验、Kaplan-Meier法等方法比较具有恶性肿瘤家族史的食管癌患者与无恶性肿瘤家族史的患者生存时间的差异。结果:患者的平均发病年龄与遗传易感性无关;食管癌家族史阳性组的生存时间(月)明显高于阴性组(59.83±3.60vs.37.47±1.95,P=0.002),食管癌家族史阳性组和恶性肿瘤家族史阳性组中,<60岁者的生存曲线明显高于≥60岁组者(P<0.01),而阴性组则无差异。结论:食管癌家族史阳性的患者预后较好;食管癌家族史和恶性肿瘤家族史阳性的青壮年食管癌患者预后较好。食管癌患者的预后与家族史及发病年龄相关。
Objective: To investigate the influence of genetic predisposition of malignant tumor on the prognosis of esophageal cancer patients with high incidence of esophageal cancer in the Taihang Mountains. Methods: The age, sex, family history of esophageal cancer, family history of malignant tumor, and family history of 742 cases of esophageal cancer in Linzhou City and its surrounding area were retrospectively investigated. By using t test, Kaplan-Meier Method and other methods to compare the survival time of patients with esophageal cancer family history of malignant tumor and family history of malignant tumors. Results: The mean age at onset of the disease was not related to the genetic predisposition. The survival time (month) in the positive group with esophageal cancer family history was significantly higher than that in the negative group (59.83 ± 3.60 vs. 37.47 ± 1.95, P = 0.002). The positive family history of esophageal cancer The survival curves of patients <60 years old were significantly higher than those of patients ≥60 years old (P <0.01), but no difference was found in the negative group. Conclusion: The prognosis of esophageal cancer patients with positive family history is good. The prognosis of esophageal cancer patients with family history of esophageal cancer and family history of malignant tumors is good. The prognosis of patients with esophageal cancer and family history and age of onset.