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在pH 8.11的Tris-盐酸溶液中,奥扎格雷钠与灿烂绿反应生成离子缔合物,使瑞利光散射(RLS)信号大大增强,最大瑞利散射峰位于370 nm,奥扎格雷钠的质量浓度在0.007～0.25 mg/L范围内与体系的瑞利光散射增强强度ΔIRLS呈线性关系,检出限为0.006 8 mg/L,据此建立了测定奥扎格雷钠的瑞利光散射新方法.该方法简便、快速、灵敏,可用于市售奥扎格雷钠药物中奥扎格雷钠含量的测定.“,”In a Tris-hydrochloric acid buffer solution of pH 8.11,ozagrel sodium reacts with brilliant green to form an ionic association,which causes Rayleigh light scattering (RLS) signal to enhance greatly.The maximum Rayleigh scattering peak locates at 370 nm.The mass concentration of ozagrel sodium in the range of 0.007-0.25 mg·L-1 has a linear relation with the RLS enhanced intensity ΔIRLS of the system,and the detection limit is 0.006 8 mg· L-1.Based on these results,a new RLS method for the determination of ozargrel sodium is established,which is simple,rapid and highly sensitive,and can be used to determine the content of ozagrel sodium in commercial available ozagrel sodium medicament.