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根据苯骈吡南类钾通道启开剂的构效关系,运用药物设计原理设计合成了19个4-酰氧基苯骈吡喃类化合物,测试了其体内外生物活性,并用逐步判别分析方法研究了该类化合物的构效关系。
According to the structure-activity relationship of benzodiazepines potassium channel openers, 19 4-acyloxybenzopyranoids were designed and synthesized using the drug design principle, and their biological activity in vitro and in vivo were tested. The results of stepwise discriminant analysis The structure-activity relationship of these compounds has been studied.