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目的比较放疗同时加榄香烯与单纯放疗治疗脑转移癌的近期疗效。方法对脑转移癌患者55例进行回顾性分析,其中综合治疗(放射治疗+榄香烯)27例,单纯放疗28例。采用常规分割照射全脑总剂量40 Gy/4.5周。给药方法放疗同时每日经中心静脉给榄香烯400 mg。结果放疗开始后两周内综合治疗临床症状缓解率(77.8%)明显优于单纯放疗(53.6%);两组肿瘤消退率(CR)分别为70.4%和35.7%,差异有显著性(P<0.05)。综合治疗患者的骨髓抑制少,程度轻;单纯放疗的患者骨髓抑制多,程度重。结论榄香烯对脑转移癌放疗有协同作用,可以促进肿瘤消退,同时能减轻放疗对骨髓的抑制作用。
Objective To compare the short-term effects of radiotherapy with elemene and radiotherapy alone in the treatment of brain metastases. Methods Retrospective analysis of 55 patients with brain metastases, including 27 cases of radiotherapy combined with radiotherapy (Elemene + radiotherapy) and 28 cases of radiotherapy alone. The whole brain was irradiated 40 Gy / 4.5 weeks with conventional fractionation. Radiation therapy at the same time by daily intravenous elemene 400 mg. Results The rate of clinical symptom remission (77.8%) was better than radiotherapy alone (53.6%) within two weeks after the start of radiotherapy. The tumor regression rates (CR) of the two groups were 70.4% and 35.7% respectively, with significant difference (P < 0.05). Bone marrow suppression combined treatment of patients with less, to a lesser extent; simple radiotherapy in patients with bone marrow suppression more, the degree of weight. Conclusion Elemene has a synergistic effect on radiotherapy of brain metastases, which can promote tumor regression and reduce the inhibitory effect of radiotherapy on bone marrow.