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以乙酰乙酸乙酯、4-羟基苯甲醛、碳酸氢铵和二溴烷烃为原料,经两步反应合成溴烷氧基1,4-二氢吡啶;再将其与5-对羟基苯基-10,15,20-三苯基卟啉缩合,得到了12种新型的卟啉-二氢吡啶及其金属锌配合物,结构通过NMR,IR和HRMS进行详细表征.研究中测试了这些复杂的卟啉-二氢吡啶化合物对金黄色葡萄球菌(Staphylococcus aureus,ATCC 25923)和大肠杆菌(Escherichia coli,ATCC 25922)的抑菌活性,实验结果显示这12种化合物都有很好的抑菌活性,其中对金黄色葡萄球菌抑菌效果较好,且卟啉-二氢吡啶二元化合物的抑菌效果优于两种单体.
Bromoacetyl 1,4-dihydropyridine was synthesized by two steps using ethyl acetoacetate, 4-hydroxybenzaldehyde, ammonium bicarbonate and dibromoalkane as raw materials, and then reacted with 5-p-hydroxyphenyl- 10,15,20-triphenylporphyrin, 12 new porphyrin-dihydropyridines and their metal zinc complexes were obtained and the structures were characterized by NMR, IR and HRMS.These complex The antibacterial activity of porphyrin-dihydropyridine compounds against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 25922) showed that these 12 compounds all had good antibacterial activity, The antibacterial activity against Staphylococcus aureus was better, and the antibacterial activity of the porphyrin-dihydropyridine binary compound was better than that of two monomers.