论文部分内容阅读
目的 :探讨窦房结功能损伤 (SND)模型的方法学和电生理特征。方法 :甲醛湿敷法建立SND兔模型 ,心内电生理方法评价 SND模型窦房结电生理改变。结果 :急性 SND模型的 SCL、SNRT、SNRTc和 TSACT均较对照组明显延长 (P均 <0 .0 1 ) ,慢性 SND模型基础与植物神经阻滞后的 SNRT和 SNRTc均明显长于对照组 (P均 <0 .0 1 ) ,IHRo明显低于对照组 (P<0 .0 1 ,SND模型组心房超速起搏后交接区逸搏和继发性窦静止发生率为 35.1 % ,对照组无 1例发生。SND前后 SCL差值 (ΔSCL) >1 0 0 ms的兔模型植物神经阻滞后的 SNRTc长于≤ 1 0 0 ms组 ,IHRo低于≤ 1 0 0 ms组 ,交接区逸搏和继发性窦静止发生率 (41 .6% )亦高于≤ 1 0 0 ms组 (2 3.1 % )。结论 :SND兔模型的窦房结自律性降低 ,部分模型出现房超速起搏后交接区逸搏和继发性窦静止 ,与临床病窦征的电生理反应基本一致。以 SND后 ΔSCL>1 0 0 ms作为确定慢性 SND模型成功建立的标准其电生理特征与病窦征相关性更好
Objective: To explore the methodological and electrophysiological characteristics of the sinus node dysfunction (SND) model. Methods: SND rabbit model was established by formaldehyde wet compressing method. The electrophysiological method was used to evaluate the electrophysiological changes of sinoatrial node in SND model. Results: The SCL, SNRT, SNRTc and TSACT in acute SND model were significantly longer than those in control group (all P <0.01). The SNRT and SNRTc in chronic SND model and control group were significantly longer than those in control group (P (All P <0.01), IHRo was significantly lower than that of the control group (P <0.01). The incidence of esophageal rhythm and secondary sinus stagnation in the SND model group after atrial pacing was 35.1% In the rabbit model with SCL difference (ΔSCL)> 100 ms before and after SND, the SNRTc of the rabbit model was longer than ≤10 ms and the IHRo was lower than ≤10 ms, The incidence of sinus at rest (41.6%) was also higher than that of ≤10 ms (21.1%) .Conclusion: SND in rabbits decreased in autonomic nervous system, and in some models, Yat stroke and secondary sinus quiescence, and clinical signs of sinus electrophysiological response is basically the same.After SND ΔSCL> 100 ms as a model for establishing a successful chronic SND established its electrophysiological characteristics and sick sinus syndrome more it is good