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目的:分析慢性阻塞性肺疾病继发侵袭性真菌感染的特点,并探讨应用抗真菌药物治疗的临床疗效,从而有效改善患者预后。方法:回顾性分析衢州市衢江区人民医院2011年1月-2014年12月100例慢性阻塞性肺疾病继发侵袭性真菌感染的特点。其中50例采用氟康唑治疗,对照组;另50例采用米卡芬净治疗,为观察组;比较两组治疗疗效及治疗期间所发生不良反应。结果:通过分析发现,患者主要以肺部感染真菌为主,共检出真菌者65例;其中白色念珠菌感染者27例,其次为曲霉菌16例,光滑念珠菌12例,热带念珠菌10例。经治疗发现,观察组治疗有效率68.0%,明显高于对照组44.0%,P<0.05。对照组出现2例肝功能损害,但症状轻微,观察组未见不良反应发生。结论:慢性阻塞性肺疾病继发侵袭性真菌感染大多为肺部感染,且以白色念珠菌感染为主,通过采用米卡芬净治疗可取得显著疗效。
Objective: To analyze the characteristics of secondary invasive fungal infection in patients with chronic obstructive pulmonary disease (COPD), and to explore the clinical efficacy of antifungal drug therapy to improve the prognosis of patients. Methods: The characteristics of 100 cases of secondary invasive fungal infection of chronic obstructive pulmonary disease were retrospectively analyzed from January 2011 to December 2014 in Quzhou People’s Hospital. Among them, 50 cases were treated with fluconazole and the control group. The other 50 cases were treated with micafungin, and the other two groups were treated with fluconazole. The curative effect and the adverse reactions during the treatment were compared. Results: According to the analysis, 65 cases of fungi were detected in the lungs, including 27 cases of Candida albicans infection, 16 cases of Aspergillus, 12 cases of Candida glabrata, 10 example. After treatment, the observation group, the effective rate was 68.0%, significantly higher than the control group 44.0%, P <0.05. Two cases of liver damage in the control group, but the symptoms were mild, no adverse reactions observed in the observation group. CONCLUSIONS: Most of the invasive fungal infections secondary to COPD are pulmonary infections. The majority are Candida albicans infection, and significant effects can be achieved by using micafungin.