论文部分内容阅读
目的探讨高频电刀宫颈环切术(LEEP)联合干扰素治疗高危型人乳头瘤病毒(HPV)感染合并宫颈癌前病变的临床疗效。方法将金陵医院收治的94例高危型HPV感染合并宫颈癌前病变患者随机分为两组,每组47例,对照组患者应用LEEP刀进行治疗,联合组在应用LEEP刀治疗后加用干扰素,对比两组患者术后并发症发生率、生活质量及HPV阳性率的变化。结果联合组患者术后创面愈合时间明显短于对照组,差异有统计学意义(P<0.05)。联合组患者术后并发症总发生率为10.64%,对照组为27.66%,组间比较差异有统计学意义(P<0.05)。联合组的宫颈上皮内瘤变(CIN)治愈率为97.87%,显著高于对照组的82.98%,差异有统计学意义(P<0.05)。联合组术后6、12个月的HPV阳性率均显著低于对照组,差异有统计学意义(P<0.05)。联合组术后的生活质量总评分显著高于对照组,差异有统计学意义(P<0.05)。结论高危型HPV感染合并宫颈癌前病变患者联合应用LEEP刀和干扰素进行治疗,能够有效提高HPV清除率,促进创面愈合,减少手术并发症的发生,降低宫颈癌前病变复发风险。
Objective To investigate the clinical efficacy of high-frequency electrocastorial cervix (LEEP) combined with interferon in the treatment of high-risk human papillomavirus (HPV) infection combined with cervical precancerous lesions. Methods Ninety-four patients with high-risk HPV infection and cervical precancerous lesions admitted to Jinling Hospital were randomly divided into two groups (n = 47 in each group). Patients in the control group were treated with LEEP knife and combined with LEEP knife plus interferon The incidence of postoperative complications, quality of life and HPV positive rate in two groups were compared. Results The wound healing time in the combined group was significantly shorter than that in the control group (P <0.05). The incidence of postoperative complications was 10.64% in the combined group and 27.66% in the control group, with significant difference between the two groups (P <0.05). The cure rate of cervical intraepithelial neoplasia (CIN) in the combined group was 97.87%, which was significantly higher than that in the control group (82.98%), the difference was statistically significant (P <0.05). The positive rates of HPV in 6 and 12 months after operation in the combined group were significantly lower than those in the control group (P <0.05). The total quality of life in the combined group was significantly higher than that in the control group, the difference was statistically significant (P <0.05). Conclusion High-risk HPV infection with cervical precancerous lesions combined with LEEP knife and interferon for treatment can effectively improve the HPV clearance rate, promote wound healing, reduce the incidence of complications and reduce the risk of cervical precancerous lesions.