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目的研究壮药龙利叶水提物的止咳、祛痰作用及祛痰的最佳给药时间。方法采用氨水引咳法评价龙利叶水提物的止咳作用,采用小鼠酚红分泌法评价龙利叶水提物的祛痰作用以及辰时和亥时给药的祛痰效果的区别。结果龙利叶水提物低、中、高剂量(5、10、15 g·kg-1)均能有效抑制由氨水引发的小鼠咳嗽,增强小鼠酚红分泌量;在祛痰效果上,辰时和亥时给药与空白组比较有效,但两者间并无显著差异。结论龙利叶水提物对小鼠由氨水引发的咳嗽有较好的抑制作用;对小鼠的酚红分泌有较显著的作用,且辰时和亥时给药均有疗效。
Objective To study the antitussive and expectorant effects of the water extract of Radix Aconiti Lateralis and the optimal administration time of expectorant. Methods The antitussive action of Aqueous extract of Longye Liye was evaluated by ammonia water cough-inducing method. The expectorant effect of aqueous extract of Ulva leaf was evaluated by the mouse phenol red secretion method and the difference of expectorant effect between the administration of Chenlong and Haihe oil. Results Long, low, medium and high doses of 5, 10, 15 g · kg-1 water extract could effectively inhibit the cough caused by ammonia-induced mice and enhance the phenol red secretion of mice. In the expectorant effect The administration at the time of Chen and Hai was more effective than the blank group, but there was no significant difference between the two groups. Conclusion Long Li Ye water extract on mice caused by ammonia-induced cough better inhibition of phenol red secretion in mice have a more significant role, and the time Chen and Hai administration are curative effect.