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目的 :探讨鼻咽癌患者鼻咽分泌物中肿瘤坏死因子 α(TNF- α)含量变化的临床意义。方法 :用特制装置收集 2 0例健康者和 5 2例鼻咽癌患者的鼻咽分泌物 ,应用放射免疫技术进行 TNF- α含量测定。结果 :对照组鼻咽分泌物中 TNF- α含量为 (12 .95± 4.6 2 ) pmol/ L,肿瘤组为 (33.6 8± 15 .13) pm ol/ L,肿瘤坏死组为 (6 4.0 0±11.5 7) pm ol/ L。肿瘤组含量明显高于对照组 ,其差异有极显著性意义 (P <0 .0 1) ;肿瘤坏死组含量进一步升高 ,与肿瘤组比较 ,其差异亦有极显著性意义 (P<0 .0 1)。结论 :鼻咽癌患者鼻咽分泌物中 TNF- α含量高于正常人 ,测定鼻咽分泌物中 TNF- α含量有助于鼻咽癌的诊断。
Objective: To investigate the clinical significance of the changes of tumor necrosis factor α (TNF-α) in nasopharyngeal secretions of patients with nasopharyngeal carcinoma. Methods: Nasopharyngeal secretions from 20 healthy subjects and 52 patients with nasopharyngeal carcinoma were collected with a special device. The content of TNF-α was determined by radioimmunoassay. Results: The content of TNF-α in the nasopharyngeal secretions of the control group was (12.95 ± 4.6 2) pmol / L, the tumor group was (33.6 8 ± 15.13) pm ol / L and the tumor necrosis group was ± 11.5 7) pm ol / L. The content of tumor in the tumor group was significantly higher than that in the control group (P <0.01). The content of tumor necrosis group was further increased, the difference was also significant compared with the tumor group (P <0 .0 1). Conclusion: The content of TNF-α in nasopharyngeal secretions of nasopharyngeal carcinoma patients is higher than that of normal people. The determination of TNF-α content in nasopharyngeal secretions is helpful for the diagnosis of nasopharyngeal carcinoma.