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我科于1988年8月至1992年1月收治2名患克隆氏病的同胞兄弟,现报道这两名克隆氏病及其家系调查结果于下。例1男,年龄28个月。因反复高热,消瘦及腹痛半个月于1988年8月入院。母孕期及出生史无特殊。查体:消瘦、苍白、口粘膜疱疹样溃疡。心肺无异常,腹部平坦无包块、压痛不明显,四肢活动正常。血WBC12×10~9/L,S0.46、L0.52。便常规未见异常。血沉44mm/h,T50g/L,A31.8g/L,G29g/L。纤维结肠镜检查,病理报告:可见大量淋巴细胞、浆细胞,中性粒细胞,表面被覆鳞状上皮,假上皮瘤样增生。终因大量血便,极度消瘦,半年后死亡。
My department from August 1988 to January 1992 admitted two Crohn’s disease siblings, are now reported two Crohn’s disease and its pedigree survey results in the next. Example 1 male, age 28 months. Due to repeated high fever, weight loss and abdominal pain for half a month in August 1988 admitted. Pregnancy and birth no special history. Physical examination: thin, pale, mouth mucosal herpes-like ulcers. No abnormal heart and lung, abdominal flat without mass, tenderness is not obvious, normal limbs. Blood WBC12 × 10 ~ 9 / L, S0.46, L0.52. It is normal no abnormalities. ESR 44mm / h, T50g / L, A31.8g / L, G29g / L. Fiber colonoscopy, pathological reports: a large number of visible lymphocytes, plasma cells, neutrophils, surface-covered squamous epithelium, pseudopothelioma-like hyperplasia. The end result of a large number of bloody stools, extremely thin, six months after death.