四十多年来应用抗生素治疗疾病成绩显著。抗生素品种不断增加,以双环结构的β-内酰胺类占主要地位。据1981年日本统计,各种抗生素生产额的构成比中,双环结构的β-内酰胺类抗生素占72％。1985年美国研究部门报告,半合成青霉素和头孢菌素抗生素类,已有上千种,当然有临床实用价值的远没有这么多。 More than 40 years of antibiotic treatment of disease results. Antibiotics species continue to increase, with bicyclic structure of β-lactams dominated. According to Japan’s 1981 statistics, among the constituent ratios of various antibiotic production amounts, β-lactam antibiotics with a bicyclic structure accounted for 72%. In 1985, the U.S. research department reported that thousands of semisynthetic penicillin and cephalosporin antibiotics have existed, of course, there are far less clinical practical value.