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[目的]探讨饮水砷暴露与糖尿病是否有相关性。[方法]检索纳入国内外有关饮水砷暴露与糖尿病关系的文献4篇,采用Meta分析的方法,应用随机效应模型和固定效应模型进行综合的定量分析,计算合并OR值及OR值的95%CI,利用倒漏斗图法定性评价发表性偏倚。[结果]暴露组的糖尿病患病率高于非暴露组(OR=2.84,95%CI为1.90~4.23);男性暴露组比非暴露组糖尿病的患病率高(OR=3.15,95%CI为1.12~8.88);女性暴露组比非暴露组糖尿病的患病率高(OR=2.54,95%CI为2.45-2.65)。由于Meta分析结果不符合要求,未进行倒漏斗图分析。[结论]饮水砷暴露可能会引起糖尿病的高发,饮水砷暴露可能是糖尿病的危险因素之一。
[Objective] To investigate whether drinking arsenic exposure is related to diabetes mellitus. [Methods] There were 4 literatures about the relationship between arsenic exposure in drinking water and diabetes mellitus in China and other countries. Meta-analysis methods were used to conduct a comprehensive quantitative analysis using random effects model and fixed effects model. The combined OR and 95% CI , The use of inverted funnel chart method of qualitative evaluation of published bias. [Results] The prevalence of diabetes in the exposed group was higher than that in the non-exposed group (OR = 2.84, 95% CI 1.90-4.23). The prevalence of diabetes in the exposed group was higher than that in the non-exposed group (OR = 3.15, 95% CI (1.12 ~ 8.88). The prevalence of diabetes in female exposed group was higher than that in non-exposed group (OR = 2.54, 95% CI 2.45-2.65). Since the Meta analysis did not meet the requirements, no funnel analysis was conducted. [Conclusion] Arsenic exposure to drinking water may cause high incidence of diabetes. Arsenic exposure to drinking water may be one of the risk factors of diabetes.