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目的观察早期小剂量肝素治疗重症感染患者的疗效。方法重症感染成年患者22例,随机分为两组:实验组和对照组。对照组行常规ICU治疗,实验组除常规治疗外,早期应用小剂量肝素。在入ICU后每日检测记录患者凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血小板计数、APACHEⅡ评分、入ICU的时间、住院时间、治愈率、28 d生存率。结果治疗后实验组PT、APTT改善,对照组PT,APTT无明显变化,两组间血小板变化无差异;实验组入ICU的时间明显少于对照组(P<0．01);实验组治愈率(81．8％)明显高于对照组(54．5％);实验组住院时间和28 d生存率与对照组之间无显著差异(P>0．05)。结论早期小剂量肝素治疗可改善重症感染患者的凝血指标,减少患者在ICU的住院时间,提高其治愈率,但未能改善生存率。
Objective To observe the efficacy of early low-dose heparin in patients with severe infection. Methods 22 cases of severe infection in adult patients were randomly divided into two groups: the experimental group and the control group. Control group routine ICU treatment, experimental group in addition to conventional treatment, the early application of low-dose heparin. The daily prothrombin time (PT), activated partial thromboplastin time (APTT), platelet count, APACHE II score, time to ICU, length of hospital stay, cure rate and 28-day survival were recorded and recorded daily after ICU admission. Results After treatment, the PT and APTT in the experimental group were improved. There was no significant change in the PT and APTT in the control group. There was no difference in the platelet count between the two groups. The time for the ICU in the experimental group was significantly less than that in the control group (P <0.01) (81.8%) was significantly higher than that of the control group (54.5%). There was no significant difference between the experimental group and the control group in hospitalization time and 28-day survival rate (P> 0.05). Conclusion Early low-dose heparin treatment can improve the coagulation index of patients with severe infection, reduce the length of hospital stay in patients with ICU, and improve the cure rate, but failed to improve the survival rate.