论文部分内容阅读
目的探讨进展期胃癌术中腹腔内行区域性植入5-氟尿嘧啶缓释化疗的临床疗效及用药安全进行分析评价。方法将60例进展期胃癌患者均进行手术根治切除术后并随机分为两组,治疗组:30例患者给予术中行区域性缓释化疗;对照组30例患者与治疗组患者术后均进行常规全身化疗,并对其两组患者治疗后临床疗效进行疗效评价及安全性评价。结果疗效判定治疗组:完全缓解8例占26.7%、部分缓解11例占36.7%、疾病稳定7例占23.3%、疾病进展4例占13.3%。对照组:完全缓解5例占1.7%、部分缓解9例占30.0%、疾病稳定11例占36.7%、疾病进展5例占16.7%。两组患者在治疗后腹腔相关并发症与化疗毒副作用无显著差异。结论进展期胃癌术中腹腔内行区域性植入5-氟尿嘧啶缓释化疗,患者耐受性良好,用药后临床疗效增加而未见明显的全身、局部不良反应。
Objective To investigate the clinical efficacy and drug safety of regional implantation of 5-fluorouracil sustained-release chemotherapy in patients with advanced gastric cancer undergoing intra-abdominal surgery. Methods Sixty patients with advanced gastric cancer underwent radical resection and were randomly divided into two groups. The treatment group: 30 patients received regional sustained-release chemotherapy; 30 patients in the control group and the treatment group were performed postoperatively Routine systemic chemotherapy, and the clinical efficacy of two groups of patients after treatment efficacy evaluation and safety evaluation. Results Efficacy of the treatment group: complete remission in 8 cases accounted for 26.7%, partial remission in 11 cases accounted for 36.7%, stable disease in 7 cases accounted for 23.3%, disease progression in 4 cases accounted for 13.3%. In the control group, complete remission was achieved in 5 cases (1.7%), partial remission in 9 cases (30.0%), stable disease in 11 cases (36.7%), and disease progression in 5 cases (16.7%). There was no significant difference between the two groups in the complications of peritoneal cavity after chemotherapy and the side effects of chemotherapy. Conclusion Intraperitoneal implantation of 5-fluorouracil sustained-release chemotherapy in patients with advanced gastric cancer is performed well. The patients are well-tolerated and the clinical curative effect increases after treatment without obvious systemic and local adverse reactions.