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目的:考察临床药师干预重症监护室(ICU)肝肾功能损害患者应用抗菌药物的临床效果。方法:分别随机抽取我院2009年6-12月(干预前)和2011年6-12月(干预后)入住ICU的肝肾功能损害患者病历各100份,对抗菌药物用药频度(DDDs)和药物利用指数(DUI)值、抗菌药物联合用药情况、抗菌药物用药合理性、死亡率等指标进行回顾性分析。结果:经临床药师干预后,我院ICU患者应用抗菌药物的合理性有明显的改善,合理率由67.83%上升至83.59%(χ2=9.394,P=0.007<0.05)。结论:临床药师对ICU肝肾功能损害患者应用抗菌药物的干预是可行并且有效的,对该类患者用药的安全、有效、合理、经济具有积极的促进作用。
Objective: To investigate the clinical pharmacist clinical application of antibacterials in patients with intensive care unit (ICU) impaired liver and kidney function. Methods: 100 cases of liver and kidney dysfunction admitted to ICU in our hospital from June to December 2009 (before intervention) and from June to December in 2011 (after intervention) were randomly selected. The frequency of antimicrobial medication (DDDs) And drug utilization index (DUI) values, antimicrobial drug use, antimicrobial drug rationality, mortality and other indicators were retrospectively analyzed. Results: After the intervention of clinical pharmacists, the rationality of using antimicrobial agents in ICU patients in our hospital was significantly improved. The reasonable rate increased from 67.83% to 83.59% (χ2 = 9.394, P = 0.007 <0.05). Conclusion: It is feasible and effective for clinical pharmacists to use antibacterials in ICU patients with hepatic and renal dysfunction, and it is positive, effective, rational and economical to promote drug use in these patients.