Pseudo-pure state (PPS) preparation is crucial in nuclear magnetic resonance quantum computation.There have been some methods in spin-1/2 systems and a few attempts in quadrupolar spin systems.As optimal control via gradient ascent pulses engineering (GRAPE) has been widely used in quantum information science,we apply this technique to PPS preparation in quadrupolar spin systems.This approach shows an effective and fast quantum control method for both the state preparation and the realization of quantum gates in quadrupolar systems.