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目的分析评价急性胰腺炎患者检测降钙素原与C反应蛋白的临床诊断价值以及对治疗的意义。方法 84例急性胰腺炎患者,按照随机双盲法分成急性胰腺炎感染组和急性胰腺炎非感染组,各42例。另选择同期非急性胰腺炎健康人42例作为非急性胰腺炎健康人组。分别检测三组血清降钙素原和C反应蛋白水平,并进行比较。结果急性胰腺炎感染组患者降钙素原为(5.2±0.6)μg/L、急性胰腺炎非感染组为(1.8±0.5)μg/L、非急性胰腺炎健康人组为(0.7±0.3)μg/L,急性胰腺炎感染组和急性胰腺炎非感染组患者降钙素原高于非胰腺炎健康人组,差异具有统计学意义(P<0.01);急性胰腺炎感染组患者降钙素原高于急性胰腺炎非感染组患者,差异具有统计学意义(P<0.05)。急性胰腺炎感染组患者C反应蛋白为(171.6±26.8)mg/L、急性胰腺炎非感染组为(114.2±20.8)mg/L、非急性胰腺炎健康人组为(10.2±1.8)mg/L,急性胰腺炎感染组和急性胰腺炎非感染组患者降钙素原高于非胰腺炎健康人组,差异具有统计学意义(P<0.01);急性胰腺炎感染组患者降钙素原高于急性胰腺炎非感染组,差异具有统计学意义(P<0.05)。结论通过检测患者降钙素原和C反应蛋白能够客观的对急性胰腺炎进行早期诊断,并且对患者感染的程度具有优良的敏感性,可以对疾病的进展和预后情况做出有效的评价,具有广泛的临床应用前景。
Objective To analyze and evaluate the clinical value of procalcitonin and C-reactive protein in patients with acute pancreatitis and their clinical significance. Methods Eighty-four patients with acute pancreatitis were randomly divided into acute pancreatitis group and non-infected group with 42 cases in each group. Another 42 patients with non-acute pancreatitis during the same period were chosen as healthy non-acute pancreatitis group. Three groups of serum procalcitonin and C-reactive protein levels were detected and compared. Results The levels of procalcitonin in acute pancreatitis group were (5.2 ± 0.6) μg / L, those in non-infected group were (1.8 ± 0.5) μg / L and those in non-acute pancreatitis group were (0.7 ± 0.3) The levels of procalcitonin in acute pancreatitis group and non-infected group were significantly higher than those in non-pancreatitis group (P <0.01). The levels of calcitonin The original higher than the non-infected group of patients with acute pancreatitis, the difference was statistically significant (P <0.05). The level of C-reactive protein in patients with acute pancreatitis was (171.6 ± 26.8) mg / L, that of non-infected patients with acute pancreatitis was (114.2 ± 20.8) mg / L and that of non-acute pancreatitis was (10.2 ± 1.8) mg / L, acute pancreatitis infection group and acute pancreatitis non-infected group patients with procalcitonin than non-pancreatitis healthy group, the difference was statistically significant (P <0.01); acute pancreatitis infection group patients with high procalcitonin In non-infected group of acute pancreatitis, the difference was statistically significant (P <0.05). Conclusions The detection of procalcitonin and C-reactive protein can objectively diagnose acute pancreatitis objectively and have an excellent sensitivity to the degree of infection of the patient, so as to effectively evaluate the progress and prognosis of the disease. A wide range of clinical applications.