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目的采用脑磁图(magnetoencephalography,MEG)的等价电流偶极子定位法(Equivalent current dipole,ECD)和合成孔径磁场定位法(SAM Synthetic Aperture Magnetometry,SAM)定位母语为汉语的健康自愿者的语言中枢,探讨汉字的语言处理过程。方法对10例母语为汉语的健康受试者给予默读真词、假词的语言任务刺激,记录刺激后产生的诱发磁场,将采集的数据与MRI叠加获得磁源性影像(MSI Magnetic source imaging)语言功能区定位。用同样的方法对4例胶质瘤患者进行术前语言功能区定位,术中皮层电刺激所定位语言功能区,明确是否产生言语障碍。结果所有受试者真词、假词均在双侧大脑半球诱发出明显的晚期磁反应波,左侧大脑半球磁反应波分化较右侧大脑半球好,Broca区位于额下同后部,Wernicke区位于颞中回、颞上回、缘上回,Wernicke区先于Broca区出现。胶质瘤患者术中电刺激所定位的Broca区、Wernicke区均产生言语障碍。结论母语为汉语的正常人的Broca区与Wernicke区与经典的语言中枢基本相符,MEG定位语言中枢的技术是可行的。
Objective To locate the language of healthy volunteers whose native language is Chinese using Equivalent Current Dipole (ECD) and Synthetic Aperture Magnetometry (SAM) with magnetoencephalography (MEG) Central, explore the language processing of Chinese characters. Methods Ten healthy volunteers whose mother tongue was Chinese were stimulated by the language task of reading real words and fake words and the induced magnetic field was recorded. The acquired data were superimposed on MRI to obtain MSI magnetic source imaging. Language ribbon positioning. Using the same method, 4 cases of glioma patients were preoperatively language functional area positioning, intraoperative cortical stimulation of locating the language function areas, clear whether to produce speech disorders. Results All participants’ real words and fake words induced obvious late magnetic resonance wave in the bilateral cerebral hemispheres. The left hemisphere magnetic resonance wave differentiation was better than that of the right hemisphere. The Broca area was located at the frontal and posterior part. Wernicke The region is located in the middle of the temporal gyrus, the superior temporal gyrus, and the margin of the upper limb. The Wernicke region precedes the Broca region. Glioma patients undergoing electrical stimulation of the positioning of the Broca area, Wernicke area have speech disorders. Conclusion The Broca and Wernicke districts of native speakers of Chinese are basically in line with the classical linguistic centers, and the technology of MEG locating the language center is feasible.