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目的观察放疗联合卡培他滨同步化疗术前治疗局部晚期直肠癌的疗效及不良反应。方法 94例局部晚期直肠癌患者随机分为对照组43例,采用盆腔单独放疗;治疗组51例,采用卡培他滨化疗联合同期放疗。观察两组疗效。结果治疗组完全缓解率17.6%、总有效率78.4%,均明显高于对照组9.3%、58.1%,两组总有效率比较差异有统计学意义(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论放疗联合卡培他滨同步化疗术前新辅助治疗局部晚期直肠癌患者疗效较好,且不良反应较轻,是一个较为安全、有效、值得临床推广应用的治疗措施。
Objective To observe the efficacy and adverse reactions of radiotherapy combined with capecitabine in the treatment of locally advanced rectal cancer. Methods Ninety-four patients with locally advanced rectal cancer were randomly divided into control group (43 cases) treated with pelvic radiotherapy alone and 51 cases (treatment group) treated with capecitabine chemotherapy combined with concurrent radiotherapy. Observe the efficacy of the two groups. Results The complete remission rate in the treatment group was 17.6% and the total effective rate was 78.4%, which was significantly higher than that in the control group (9.3%, 58.1%). There was a significant difference in the total effective rate between the two groups (P<0.05). There was no significant difference between the two groups in adverse reactions (P>0.05). Conclusion The combination of radiotherapy and capecitabine in preoperative neoadjuvant chemotherapy for locally advanced rectal cancer has better efficacy and milder adverse reactions. It is a safe, effective and worthy clinical treatment.