硬金属肺病(hard metal lung disease,HMLD)指长期吸入钨、钛、钒、钴等硬质金属粉尘或其合金粉尘引起的肺部疾病,主要包括硬质金属哮喘、慢性支气管炎及肺纤维化等病变[1-3]。HMLD引起弥漫性间质肺损害,最终可以发展成纤维化,造成暴露硬金属粉尘者永久性肺损伤,临床主要表现为 Hard metal lung disease (HMLD) refers to long-term inhalation of tungsten, titanium, vanadium, cobalt and other hard metal dust or its alloy dust caused lung disease, including hard metal asthma, chronic bronchitis and pulmonary fibrosis Other lesions [1-3]. HMLD causes diffuse interstitial lung damage, eventually can develop into fibrosis, resulting in exposure to hard metal dust permanent lung injury, the clinical manifestations of