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目的:调查心血管类药物ADR的临床特点及产生原因。方法:从1998年～2001年4月公开发行的国内70余种医药学期刊中收集到心血管类药物不良反应个案776例,其中符合药物不良反应判定标准的739例,按照不良反应类别进行归纳、统计和分析。结果:心血管类药物的不良反应共涉及人体7个系统,其中呼吸系统所占的比例最大(29.8%);涉及相关药物六大类,以ACEI类药物较为常见(230例);重度不良反应46例,死亡15例,死亡占2.03％;51岁以上年龄组的不良反应(78.9％)高于其 他年龄组;口服给药(65.5％)较其他给药途径发生的比例高。结论:心血管类药物ADR的发生与药物的药理作用、给药途径、合并用药及患者的年龄、个体差异、饮食习惯等有关。
Objective: To investigate the clinical features and causes of cardiovascular drug ADR. Methods: A total of 776 cases of adverse cardiovascular reactions were collected from more than 70 kinds of domestic journals published in China from April 1998 to April 2001, of which 739 cases met the standard of adverse drug reactions and were classified according to the types of adverse reactions ,statistic and analysis. Results: The adverse reactions of cardiovascular drugs involved 7 human body systems, of which respiratory system accounted for the largest proportion (29.8%); related to the six major categories of drugs, ACEI drugs are more common (230 cases); severe adverse reactions Among 46 cases, 15 died and 2.03% died. Adverse reactions (78.9%) were higher in those over 51 than those in other age groups. Oral administration (65.5%) was more frequent than other routes of administration. Conclusion: The occurrence of cardiovascular drug ADR has something to do with the pharmacological effects of drugs, the route of administration, the combination medication and the patients’ age, individual differences and eating habits.